Maiseyeu Laboratory: About Us

The Maiseyeu laboratory is part of Case Western Reserve University and the Cardiovascular Research Institute in Cleveland, Ohio. We are located in a state-of-the-art facility on the 4th floor of the Wolstein Research Building.

Our research team develops nanotechnology tools to better understand and treat cardiometabolic and immune-related diseases, including atherosclerosis, cardiac fibrosis, type 2 diabetes, obesity, Alzheimer’s, and systemic lupus erythematosus. We engineer, fabricate, and evaluate advanced drug delivery systems, particularly polymeric nanoparticles and viral gene-delivery vectors, to improve therapeutic precision and efficacy.

Current efforts focus on polymeric nanoparticles that enhance cell-therapy delivery, explore their epigenetic and immunometabolic effects, and modulate B-cell function and immune signaling. We are also developing gene circuits that selectively silence gene expression. Complementary work continues to examine lipoprotein biology, immune-cell metabolism, and the broader toxicological impacts of synthetic and environmental nano- and microparticles on cardiometabolic health.

We welcome you to our website and hope you enjoy reading about us, our science, and what inspires us!

Explore Our Research

Navigate to our projects to discover the work we are pursuing, and feel free to contact us if you have questions or would like to get involved.

Our Philosophy

Advancing Science, Inspiring Discovery

We welcome you to our website and hope you enjoy reading about us, our science, and what inspires us. Your interest fuels our mission to combat disease.